RNF43 and UBE2D4

Number of citations of the paper that reports this interaction (PubMedID 19690564)
57

Data Source:
BioGRID (two hybrid)

		RNF43	UBE2D4
Description		ring finger protein 43	ubiquitin conjugating enzyme E2 D4 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane	Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Pancreatic cancer ( 20686608) Prostate cancer ( 29892016) Stroke ( 29531354) Vitamin D levels ( 25208829)
Interacting Genes		8 interacting genes: RSPO2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N	99 interacting genes: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 ITCH LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 PRKN RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBA1 UBC UBE4A UBOX5 UBTD1 UFM1 UHRF2 UVSSA XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		54894	51619
HPRD ID		07896	14242
Ensembl ID		ENSG00000108375	ENSG00000078967
Uniprot IDs		J3KSE3 Q68DV7	A0A024RA90 Q9UQL0 Q9Y2X8
PDB IDs		4KNG
Enriched GO Terms of Interacting Partners?
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