TET2 and TBC1D4

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		TET2	TBC1D4
Description		tet methylcytosine dioxygenase 2	TBC1 domain family member 4
Image
GO Annotations	Cellular Component	Nucleus	Cytosol Vesicle
	Molecular Function	DNA Binding Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity	GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Response To Organic Cyclic Compound Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity
Pathways		TET1,2,3 and TDG demethylate DNA	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)	Diabetic retinopathy ( 23562823) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Red blood cell count ( 29403010 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		2 interacting genes: DCAF1 TBC1D4	15 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		54790	9882
HPRD ID		07876	18164
Ensembl ID		ENSG00000168769	ENSG00000136111
Uniprot IDs		A0A024RDF7 A0A158SIU0 Q6N021	A0A3B3IRT3 O60343
PDB IDs		4NM6 5D9Y 5DEU	3QYB
Enriched GO Terms of Interacting Partners?
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