TBC1D4 and ZMIZ1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		TBC1D4	ZMIZ1
Description		TBC1 domain family member 4	zinc finger MIZ-type containing 1
Image
GO Annotations	Cellular Component	Cytosol Vesicle	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Rab GTPase Binding	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Transcription Coactivator Activity Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity SMAD Binding SUMO Ligase Activity
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Cellular Response To Insulin Stimulus Activation Of GTPase Activity	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Vitellogenesis Cell Aging Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Protein Sumoylation Positive Regulation Of T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Heart failure ( 20445134) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 27863252) Mean platelet volume ( 27863252) Red blood cell count ( 29403010 27863252) Two-hour glucose ( 25043022) Type 2 diabetes ( 29926116) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Ankylosing spondylitis ( 23749187) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23535729 20453838) Brown vs. black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cobalt levels ( 26025379) Colorectal cancer ( 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 25489960 28067908 21102463) Crohn's disease and psoriasis ( 22482804) Granulocyte count ( 27863252) Height ( 25282103 25429064 23563607 31562340) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte percentage of white cells ( 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (drugs used in diabetes) ( 31015401) Multiple sclerosis ( 31604244 22190364 24076602 19525953 21833088) Neutrophil percentage of white cells ( 27863252) Pediatric autoimmune diseases ( 26301688) Platelet distribution width ( 27863252) Prostate cancer ( 31562322) Psoriasis ( 25854761 23143594) Psoriasis vulgaris ( 26626624) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triiodothyronine/thyroxine ratio ( 30824882) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 31118516 30718926 28869590) Urate levels ( 31578528) Vitiligo ( 20526339) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		15 interacting genes: AKT1 CDK5RAP2 EP400 FBXW11 NAV1 NFAT5 PIN1 RBM12 RESF1 TASOR TET2 TOPBP1 U2SURP YWHAG ZMIZ1	5 interacting genes: AR CACHD1 CNTNAP2 PIAS3 TBC1D4
Entrez ID		9882	57178
HPRD ID		18164	12115
Ensembl ID		ENSG00000136111	ENSG00000108175
Uniprot IDs		A0A3B3IRT3 O60343	A0A024QZN6 A0JLS3 Q9ULJ6
PDB IDs		3QYB	5AIZ
Enriched GO Terms of Interacting Partners?
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