TET2

Description		tet methylcytosine dioxygenase 2
Image
GO Annotations	Cellular Component	Nucleus
	Molecular Function	DNA Binding Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Response To Organic Cyclic Compound Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Histone H3-K4 Trimethylation
Pathways		TET1,2,3 and TDG demethylate DNA
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729) Chronic obstructive pulmonary disease ( 28166215 30804561) Coffee consumption ( 31046077) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal or endometrial cancer ( 26621817) Estimated glomerular filtration rate ( 31451708) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 20881960 25429064 31562340) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte counts ( 29403010 27863252) Lymphocyte percentage of white cells ( 27863252) Melanoma ( 24980573) Molybdenum levels ( 26025379) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 27863252) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 25939597 19767753) Pulmonary function ( 21946350) Regular attendance at a religious group ( 29970889) Self-reported risk-taking behaviour ( 30271922) Tonsillectomy ( 27182965 28928442) Western dietary pattern ( 28644415)
Interacting Genes		2 interacting genes: DCAF1 TBC1D4
Entrez ID		54790
HPRD ID		07876
Ensembl ID		ENSG00000168769
Uniprot IDs		A0A024RDF7 A0A158SIU0 Q6N021
PDB IDs		4NM6 5D9Y 5DEU
Enriched GO Terms of Interacting Partners?
Tagcloud ?