SGTB and SERPINE1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SGTB	SERPINE1
Description		small glutamine rich tetratricopeptide repeat containing beta	serpin family E member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane TRC Complex	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-dependent ERAD Pathway Positive Regulation Of Chaperone-mediated Protein Folding	Chronological Cell Aging Angiogenesis Platelet Degranulation Circadian Rhythm Regulation Of Signaling Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Replicative Senescence Dentinogenesis Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone Fibrinolysin Copper
Diseases			Inherited thrombophilia
GWAS			Blood protein levels ( 30072576) Nonunion in individuals with fractures ( 30680360) Plasma plasminogen activator levels ( 24578379) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Interacting Genes		11 interacting genes: COL1A2 CWC27 EFEMP2 IL6ST LAMP3 PPIB RAI2 SERPINE1 SERPINI2 TMPO TXNDC12	20 interacting genes: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LMNA LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN
Entrez ID		54557	5054
HPRD ID		18049	01418
Ensembl ID		ENSG00000197860	ENSG00000106366
Uniprot IDs		Q96EQ0	A0A024QYT5 P05121
PDB IDs			1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 4G8O 4G8R 4IC0 5BRR 5ZLZ 6I8S 9PAI
Enriched GO Terms of Interacting Partners?
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