EXOSC4 and EXOSC9

Number of citations of the paper that reports this interaction (PubMedID 11719186)
341

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		EXOSC4	EXOSC9
Description		exosome component 4	exosome component 9
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	3'-5'-exoribonuclease Activity RNA Polymerase II Activating Transcription Factor Binding RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)
Interacting Genes		28 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LRRC8D MPP6 MPZL1 MTREX NEK1 SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B	20 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MPHOSPH6 MPP6 MTREX SUMO2 UBE2I ZDHHC17
Entrez ID		54512	5393
HPRD ID		16221	07315
Ensembl ID		ENSG00000178896	ENSG00000123737
Uniprot IDs		Q9NPD3	B4DXG8 Q06265
PDB IDs		2NN6 6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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