EXOSC4 and UPF1

Number of citations of the paper that reports this interaction (PubMedID 14527413)
141

Data Source:
HPRD (in vivo, in vitro)

		EXOSC4	UPF1
Description		exosome component 4	UPF1 RNA helicase and ATPase
Image
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton	Nuclear Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Telomeric DNA Binding
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Dosage Compensation By Inactivation Of X Chromosome Viral Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		28 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LRRC8D MPP6 MPZL1 MTREX NEK1 SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B	36 interacting genes: ABHD16A ACRV1 ACSS2 AP1G1 ATR CNN1 CSNK2B DCP1A DCP2 DHPS DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LDB1 LSM8 NADSYN1 NDRG1 NDUFB10 NOTCH3 PLEKHA5 PLEKHB2 POLR2A RHOXF2 RPRD2 SMG1 SMG5 STAU1 UPF2 UPF3A UPF3B XRN1
Entrez ID		54512	5976
HPRD ID		16221	03254
Ensembl ID		ENSG00000178896	ENSG00000005007
Uniprot IDs		Q9NPD3	A0A024R7L5 A0A024R7L8 B3KY55 Q92900
PDB IDs		2NN6 6D6Q 6D6R 6H25	2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5
Enriched GO Terms of Interacting Partners?
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