EXOSC9 and HBS1L

Number of citations of the paper that reports this interaction (PubMedID 27345150)
24

Data Source:
BioGRID (pull down)

		EXOSC9	HBS1L
Description		exosome component 9	HBS1 like translational GTPase
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Cytosol Membrane Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Polymerase II Activating Transcription Factor Binding RNA Binding Exoribonuclease Activity Protein Binding AU-rich Element Binding MRNA 3'-UTR AU-rich Region Binding	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	Translation Translational Elongation Signal Transduction Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)	Aspartate aminotransferase levels ( 29403010) Beta thalassemia/hemoglobin E disease ( 20183929) Cholesterol, total ( 24097068) Eosinophil counts ( 29403010 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736) Granulocyte count ( 27863252) HbA2 levels ( 23043469) Hematocrit ( 29403010 27863252 28017375 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hodgkin's lymphoma ( 24149102) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 27863252 28017375 28548082 19862010) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 27863252 28017375 19862010) Metabolite levels ( 23823483) Monocyte count ( 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978 27863252) Plateletcrit ( 27863252) Red blood cell count ( 29403010 28453575 20139978 27863252 28017375) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 30275531) White blood cell count ( 29403010 20139978 27863252) White blood cell types ( 21738478)
Interacting Genes		20 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MPHOSPH6 MPP6 MTREX SUMO2 UBE2I ZDHHC17	10 interacting genes: APP EXOSC4 EXOSC5 EXOSC6 EXOSC9 MAP3K1 PELO SRPK1 SRPK2 UBE2G2
Entrez ID		5393	10767
HPRD ID		07315	06582
Ensembl ID		ENSG00000123737	ENSG00000112339
Uniprot IDs		B4DXG8 Q06265	D9YZV0 Q9Y450
PDB IDs		2NN6 6D6Q 6D6R 6H25	5LZW 5LZX 5LZY 5LZZ
Enriched GO Terms of Interacting Partners?
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