EXOSC4 and TSEN15

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		EXOSC4	TSEN15
Description		exosome component 4	tRNA splicing endonuclease subunit 15
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton	Nucleoplasm Nucleolus
	Molecular Function	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	Nucleic Acid Binding Nuclease Activity
	Biological Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronotype ( 30696823) Height ( 20881960) Hip circumference adjusted for BMI ( 25673412) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412)
Interacting Genes		28 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LRRC8D MPP6 MPZL1 MTREX NEK1 SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B	4 interacting genes: EXOSC4 LMO4 NBPF3 TSEN34
Entrez ID		54512	116461
HPRD ID		16221	12292
Ensembl ID		ENSG00000178896	ENSG00000198860
Uniprot IDs		Q9NPD3	A0A2U3TZM3 B1ALV0 E9PPN1 Q8WW01
PDB IDs		2NN6 6D6Q 6D6R 6H25	2GW6
Enriched GO Terms of Interacting Partners?
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