PKP1 and KRT8

Number of citations of the paper that reports this interaction (PubMedID 10852826)
24

Data Source:
HPRD (in vitro)

		PKP1	KRT8
Description		plakophilin 1	keratin 8
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Dystrophin-associated Glycoprotein Complex Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Costamere Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis Cadherin Binding	Protein Binding Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process	Viral Process Keratinization Tumor Necrosis Factor-mediated Signaling Pathway Sarcomere Organization Response To Hydrostatic Pressure Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Cornification Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs			Tenecteplase Copper
Diseases		Ectodermal dysplasia/skin fragility syndrome
GWAS		Panic disorder ( 19165232)	Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Prostate cancer ( 21743057)
Interacting Genes		9 interacting genes: DSC1 DSG1 DSP GTF2IRD1 KRT14 KRT8 TNS2 UCHL5 VIM	35 interacting genes: ANXA1 BYSL CLK1 DEDD DMD EGFR ELOC ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KPNA2 KRT13 KRT15 KRT18 KRT31 KRT38 KRT40 MAPK1 MAPK14 MAPK3 MAPK8 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 TCHP TFIP11 TROAP WBP2
Entrez ID		5317	3856
HPRD ID		03579	01015
Ensembl ID		ENSG00000081277	ENSG00000170421
Uniprot IDs		A0A024R952 Q13835	P05787 Q7L4M3
PDB IDs		1XM9
Enriched GO Terms of Interacting Partners?
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