MAPRE1 and CLASP2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		MAPRE1	CLASP2
Description		microtubule associated protein RP/EB family member 1	cytoplasmic linker associated protein 2
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GO Annotations	Cellular Component	Golgi Apparatus Centrosome Microtubule Organizing Center Spindle Cytosol Microtubule Cytoplasmic Microtubule Focal Adhesion Cortical Microtubule Cytoskeleton Cell Projection Membrane Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End	Kinetochore Condensed Chromosome Kinetochore Cell Cytoplasm Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Kinetochore Microtubule Cytosol Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cell Leading Edge Ruffle Membrane Basal Cortex Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Cadherin Binding Microtubule Plus-end Binding	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Bundle Formation Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Migration Positive Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Protein Localization To Microtubule Microtubule Polymerization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Microtubule Anchoring Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Iron status biomarkers (transferrin saturation) ( 28334935) Polycystic ovary syndrome ( 30566500) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Metabolite levels ( 23823483)
Interacting Genes		44 interacting genes: ABCB1 APC APC2 APP AURKB BCL3 CASK CDK5RAP2 CLASP1 CLASP2 COPS5 COPS8 CSN3 CYLD DCTN1 GTSE1 HSPA1A IKBKG KAT2B KAT5 KLHL21 LMO2 LRP1 MACF1 MAPRE2 MAPRE3 NAV1 NUPR1 PIK3R4 POLE2 PQBP1 PRPF3 PSMA1 SLAIN1 SPDYE2 SRC SRPK2 STK11 TERF1 TRAF2 TRIO TROAP TUBA1A TUBB	11 interacting genes: AKT1 CLIP1 CLIP2 CSNK2A1 FEZ1 FEZ2 MAPRE1 MAPRE2 MARK3 RBFOX2 SRPK2
Entrez ID		22919	23122
HPRD ID		04379	12054
Ensembl ID		ENSG00000101367	ENSG00000163539
Uniprot IDs		Q15691	E3W994 E7ERI8 E7EW49 O75122
PDB IDs		1PA7 1TXQ 1UEG 1VKA 1WU9 1YIB 1YIG 2HKQ 2HL3 2HL5 2QJZ 2R8U 3GJO 3MTU 3MUD 3TQ7 4XA1 4XA3 4XA6 5JV3 5JVM 5JVP 5JVR 5JVS 5JVU 5JX1 5WLQ	3WOY 5NR4
Enriched GO Terms of Interacting Partners?
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