LSM7 and PFKM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LSM7	PFKM
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	phosphofructokinase, muscle
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Cell Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding U6 SnRNA Binding	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	MRNA Splicing, Via Spliceosome Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Protein Homotetramerization Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Glycolysis
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Parkinson's disease ( 28892059)	Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Longevity (90 years and older) ( 25199915) Metabolite levels ( 23823483) Pulse pressure ( 30578418)
Interacting Genes		24 interacting genes: ARF6 DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SART3 SMN1 SNRPD3 SNRPF TACC1 ZSCAN26	15 interacting genes: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		51690	5213
HPRD ID		06287	01988
Ensembl ID		ENSG00000130332	ENSG00000152556
Uniprot IDs		Q9UK45	A0A024R0Y5 A0A2R8Y891 P08237
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	4OMT
Enriched GO Terms of Interacting Partners?
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