PFKM and CAV3

Number of citations of the paper that reports this interaction (PubMedID 9252390)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PFKM	CAV3
Description		phosphofructokinase, muscle	caveolin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane	Golgi Membrane Cell Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Z Disc T-tubule Neuromuscular Junction Vesicle Sarcolemma Intracellular Membrane-bounded Organelle Membrane Raft
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	Calcium Channel Regulator Activity Protein Binding Protein C-terminus Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Alpha-tubulin Binding Ion Channel Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Protein Homotetramerization Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis	Plasma Membrane Repair Regulation Of Heart Rate Negative Regulation Of Protein Kinase Activity Triglyceride Metabolic Process Lipid Transport Endocytosis Muscle Contraction Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Muscle Cell Cellular Homeostasis Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nerve Growth Factor Receptor Activity Nucleus Localization Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Cellular Response To Organonitrogen Compound Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Glycolysis	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Limb-girdle muscular dystrophy (LGMD)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Longevity (90 years and older) ( 25199915) Metabolite levels ( 23823483) Pulse pressure ( 30578418)	Caudate activity during reward ( 28927378)
Interacting Genes		15 interacting genes: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 SUMO2 TEAD4 UBTD1	16 interacting genes: DAG1 DYSF EGFR GNAS INSR JPH2 NOS1 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RYR1 SENP1 SLC22A11 SLC8A1
Entrez ID		5213	859
HPRD ID		01988	03154
Ensembl ID		ENSG00000152556	ENSG00000182533
Uniprot IDs		A0A024R0Y5 A0A2R8Y891 P08237	P56539
PDB IDs		4OMT
Enriched GO Terms of Interacting Partners?
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