PFKM and ATP6V0A4

Number of citations of the paper that reports this interaction (PubMedID 12649290)
38

Data Source:
HPRD (in vitro, in vivo)

		PFKM	ATP6V0A4
Description		phosphofructokinase, muscle	ATPase H+ transporting V0 subunit a4
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane	Vacuolar Proton-transporting V-type ATPase, V0 Domain Cell Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Integral Component Of Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome
	Molecular Function	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glucose Catabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Protein Homotetramerization Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis	Ossification Regulation Of PH Vacuolar Acidification Excretion Sensory Perception Of Sound Insulin Receptor Signaling Pathway Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		Glycolysis	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Distal renal tubular acidosis (RTA type 1)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Longevity (90 years and older) ( 25199915) Metabolite levels ( 23823483) Pulse pressure ( 30578418)	F-cell distribution in sickle cell anaemia ( 21326311) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		15 interacting genes: ATP6V0A4 CAV3 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PFKL SIAH1 SUMO2 TEAD4 UBTD1	2 interacting genes: CYTH2 PFKM
Entrez ID		5213	50617
HPRD ID		01988	05576
Ensembl ID		ENSG00000152556	ENSG00000105929
Uniprot IDs		A0A024R0Y5 A0A2R8Y891 P08237	A0A024R791 Q9HBG4
PDB IDs		4OMT
Enriched GO Terms of Interacting Partners?
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