PDE4D and ARRB1

Number of citations of the paper that reports this interaction (PubMedID 14500724)
31

Data Source:
BioGRID (two hybrid)

		PDE4D	ARRB1
Description		phosphodiesterase 4D	arrestin beta 1
Image
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Apical Plasma Membrane Calcium Channel Complex	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Drug Binding Enzyme Binding CAMP Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding	G Protein-coupled Receptor Binding Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Estrogen Receptor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Follicle-stimulating Hormone Receptor Binding V2 Vasopressin Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding Ion Channel Binding Protein Phosphorylated Amino Acid Binding Arrestin Family Protein Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Aging Regulation Of Signaling Receptor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organism Growth Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Heart Contraction T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Cellular Response To Lipopolysaccharide Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process G Protein-coupled Receptor Signaling Pathway Phototransduction Positive Regulation Of Cell Proliferation Protein Transport Protein Ubiquitination Histone Acetylation Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Follicle-stimulating Hormone Signaling Pathway Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Membrane Organization Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation
Pathways		DARPP-32 events G alpha (s) signalling events	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants
Drugs		Adenosine monophosphate Caffeine Dyphylline Iloprost Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Apremilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Amygdala volume ( 31530798) Asthma ( 19426955) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Cognitive function ( 28808816) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) General cognitive ability ( 29844566) Immune response to smallpox vaccine (IL-6) ( 22610502) Intelligence (MTAG) ( 29326435) Mitochondrial DNA levels ( 30326835) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Plasma parathyroid hormone levels ( 30134803) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to antipsychotic treatment ( 23241943) Sleep duration (long sleep) ( 30846698) Sleep-related phenotypes ( 17903308)	Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23	54 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PRKN PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SREBF2 STAM TRHR ZBTB43
Entrez ID		5144	408
HPRD ID		02530	00146
Ensembl ID		ENSG00000113448	ENSG00000137486
Uniprot IDs		A0A140VJR0 Q08499	B7Z1Q3 P49407
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6NJH 6NJI 6NJJ 6RCW	2IV8
Enriched GO Terms of Interacting Partners?
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