ARRB1 and CXCR2

Number of citations of the paper that reports this interaction (PubMedID 11170396)
39

Data Source:
HPRD (in vivo)

		ARRB1	CXCR2
Description		arrestin beta 1	C-X-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function	G Protein-coupled Receptor Binding Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Estrogen Receptor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Follicle-stimulating Hormone Receptor Binding V2 Vasopressin Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding Ion Channel Binding Protein Phosphorylated Amino Acid Binding Arrestin Family Protein Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process G Protein-coupled Receptor Signaling Pathway Phototransduction Positive Regulation Of Cell Proliferation Protein Transport Protein Ubiquitination Histone Acetylation Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Follicle-stimulating Hormone Signaling Pathway Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Membrane Organization Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Neutrophil Degranulation Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs
Diseases
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		54 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PRKN PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SREBF2 STAM TRHR ZBTB43	21 interacting genes: ADRA1A ARRB1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 ST13
Entrez ID		408	3579
HPRD ID		00146	00907
Ensembl ID		ENSG00000137486	ENSG00000180871
Uniprot IDs		B7Z1Q3 P49407	P25025 Q53PC4
PDB IDs		2IV8	4Q3H 5TYT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?