ARRB1 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 15611106)
78

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ARRB1	AGTR1
Description		arrestin beta 1	angiotensin II receptor type 1
Image
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Cell Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Binding Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Estrogen Receptor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Follicle-stimulating Hormone Receptor Binding V2 Vasopressin Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding Ion Channel Binding Protein Phosphorylated Amino Acid Binding Arrestin Family Protein Binding	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Apoptotic Process G Protein-coupled Receptor Signaling Pathway Phototransduction Positive Regulation Of Cell Proliferation Protein Transport Protein Ubiquitination Histone Acetylation Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Follicle-stimulating Hormone Signaling Pathway Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Membrane Organization Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Diameter By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Blood Vessel Diameter Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		54 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PRKN PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SREBF2 STAM TRHR ZBTB43	21 interacting genes: ACADM AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK2 GRK3 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 PTGFR RAB5A RAF1 THOP1
Entrez ID		408	185
HPRD ID		00146	00107
Ensembl ID		ENSG00000137486	ENSG00000144891
Uniprot IDs		B7Z1Q3 P49407	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		2IV8	1ZV0 4YAY 4ZUD 6DO1
Enriched GO Terms of Interacting Partners?
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