PDE4D and ARRB2

Number of citations of the paper that reports this interaction (PubMedID 14500724)
31

Data Source:
BioGRID (two hybrid)

		PDE4D	ARRB2
Description		phosphodiesterase 4D	arrestin beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Apical Plasma Membrane Calcium Channel Complex	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Drug Binding Enzyme Binding CAMP Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Platelet Activating Factor Receptor Binding Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity 14-3-3 Protein Binding Arrestin Family Protein Binding
	Biological Process	Regulation Of Heart Rate CAMP Catabolic Process Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Aging Regulation Of Signaling Receptor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Multicellular Organism Growth Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Heart Contraction T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Cellular Response To Lipopolysaccharide Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle	Negative Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Brain Development Adult Walking Behavior Positive Regulation Of Gene Expression Protein Transport Protein Ubiquitination Protein Deubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Excitatory Postsynaptic Potential Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		DARPP-32 events G alpha (s) signalling events	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants
Drugs		Adenosine monophosphate Caffeine Dyphylline Iloprost Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Apremilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Amygdala volume ( 31530798) Asthma ( 19426955) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Cognitive function ( 28808816) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) General cognitive ability ( 29844566) Immune response to smallpox vaccine (IL-6) ( 22610502) Intelligence (MTAG) ( 29326435) Mitochondrial DNA levels ( 30326835) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Plasma parathyroid hormone levels ( 30134803) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to antipsychotic treatment ( 23241943) Sleep duration (long sleep) ( 30846698) Sleep-related phenotypes ( 17903308)	Lymphocyte counts ( 27863252)
Interacting Genes		28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23	51 interacting genes: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 EGFR FLNA FZD4 GRK2 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXER1 OXTR PDE4D PRKN PTAFR PTGDS RAF1 RALGDS RHO SLC9A5 SMARCC2 STC2 TGFBR3 TRH UBC
Entrez ID		5144	409
HPRD ID		02530	00147
Ensembl ID		ENSG00000113448	ENSG00000141480
Uniprot IDs		A0A140VJR0 Q08499	K7ENA6 P32121 Q59EM5 Q68DZ5
PDB IDs		1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6NJH 6NJI 6NJJ 6RCW
Enriched GO Terms of Interacting Partners?
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