APH1A and HIVEP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		APH1A	HIVEP1
Description		aph-1 homolog A, gamma-secretase subunit	HIVEP zinc finger 1
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GO Annotations	Cellular Component	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane	Nucleus Nucleoplasm Mitochondrion Nuclear Body
	Molecular Function	Endopeptidase Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		E-2012
Diseases
GWAS		Bipolar disorder ( 31043756) Chronotype ( 26955885) Morning vs. evening chronotype ( 26955885 26835600) Schizophrenia ( 25056061)	Alcohol and nicotine co-dependence ( 22488850) Body mass index ( 28892062 25673413 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Takayasu arteritis ( 25604533)
Interacting Genes		17 interacting genes: ATF4 BHLHE40 CEP350 CREB3 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	37 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BHLHE40 BNIP3 BRCA1 CACNA1A CLK1 DNAJA1 EMG1 GAA GSDMB HPD HSPA1A IMMT MAGED1 MAPK14 MAPK8 MTMR3 NHLH1 NINJ1 NUCB1 PRKAR1A RAB1A RIDA SDCBP SERTAD1 SMAD3 SNX4 SOCS3 SOX10 SRPK2 STAT3 TMEM176A
Entrez ID		51107	3096
HPRD ID		06360	01925
Ensembl ID		ENSG00000117362	ENSG00000095951
Uniprot IDs		B4DUG7 Q96BI3	P15822
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?
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