APH1A and KLF11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		APH1A	KLF11
Description		aph-1 homolog A, gamma-secretase subunit	Kruppel like factor 11
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GO Annotations	Cellular Component	Mitochondrion Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex Integral Component Of Presynaptic Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion Nuclear Body
	Molecular Function	Endopeptidase Activity Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Cellular Response To Peptide
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		E-2012
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Bipolar disorder ( 31043756) Chronotype ( 26955885) Morning vs. evening chronotype ( 26955885 26835600) Schizophrenia ( 25056061)	Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Feeling worry ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196) Neurociticism ( 29500382) Prostate cancer ( 23535732)
Interacting Genes		17 interacting genes: ATF4 BHLHE40 CEP350 CREB3 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10	12 interacting genes: APH1A APPBP2 ATXN1 CBX1 CBX3 CLU HDAC1 MAPK1 SIN3A TIMM13 TXNDC9 YWHAZ
Entrez ID		51107	8462
HPRD ID		06360	04488
Ensembl ID		ENSG00000117362	ENSG00000172059
Uniprot IDs		B4DUG7 Q96BI3	B7ZAX4 O14901 Q53QU8
PDB IDs		5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC	1PO4
Enriched GO Terms of Interacting Partners?
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