POLR1D and MRPL12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		POLR1D	MRPL12
Description		RNA polymerase I and III subunit D	mitochondrial ribosomal protein L12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	RNA Polymerase III Complex RNA Polymerase I Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit
	Molecular Function	DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Transcription By RNA Polymerase I Transcription By RNA Polymerase III	Mitochondrial Transcription Positive Regulation Of Transcription, DNA-templated Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases		Treacher Collins syndrome
GWAS		Body mass index ( 26426971)	LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		15 interacting genes: CD3EAP CDC25A CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN	5 interacting genes: COX6A2 OLIG1 POLR1D RARG TMEM51
Entrez ID		51082	6182
HPRD ID		17877	03849
Ensembl ID		ENSG00000186184	ENSG00000262814
Uniprot IDs		A0A087WTY1 P0DPB5 P0DPB6	P52815
PDB IDs
Enriched GO Terms of Interacting Partners?
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