PCBD1 and TRIM5

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD1	TRIM5
Description		pterin-4 alpha-carbinolamine dehydratase 1	tripartite motif containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Omegasome
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	Activation Of Innate Immune Response Autophagy Viral Process Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Phenylalanine metabolism	Interferon gamma signaling
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Coronary artery disease ( 29212778) DNA methylation (variation) ( 23725790) Mean platelet volume ( 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		49 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	38 interacting genes: BTBD1 BTBD2 EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5
Entrez ID		5092	85363
HPRD ID		00523	07004
Ensembl ID		ENSG00000166228	ENSG00000132256
Uniprot IDs		P61457	Q9C035
PDB IDs			2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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