PCBD1 and ZNF451

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PCBD1	ZNF451
Description		pterin-4 alpha-carbinolamine dehydratase 1	zinc finger protein 451
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Nucleus PML Body
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding SUMO Ligase Activity
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process	Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Histone H3-K9 Acetylation
Pathways		Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)
Interacting Genes		49 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 POLR3A RBL2 RPS24 SAP30 SCMH1 SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	29 interacting genes: AR CALCOCO2 CDC5L CDCA4 CPTP CREB1 CREBBP FAM118A FXR2 HTT JMJD6 KDM1A LZTR1 PCBD1 PIAS1 PIAS2 PIK3R3 PML PRMT1 PRMT8 PRPF40A RAP1GDS1 RNF40 SNIP1 SUMO1 SUMO2 SUV39H1 UBC UBE2I
Entrez ID		5092	26036
HPRD ID		00523	10332
Ensembl ID		ENSG00000166228	ENSG00000112200
Uniprot IDs		P61457	B4DYS2 Q96JY2 Q9Y4E5
PDB IDs			5D2M
Enriched GO Terms of Interacting Partners?
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