TRIM5 and BTBD1

Number of citations of the paper that reports this interaction (PubMedID 12878161)
45

Data Source:
HPRD (in vitro)

		TRIM5	BTBD1
Description		tripartite motif containing 5	BTB domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	P-body Cytosol Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Binding, Bridging Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Activation Of Innate Immune Response Autophagy Viral Process Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Muscle Organ Development Protein Ubiquitination Neurogenesis Regulation Of Protein Binding Post-translational Protein Modification
Pathways		Interferon gamma signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) DNA methylation (variation) ( 23725790) Mean platelet volume ( 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Platelet count ( 29403010) Serum alkaline phosphatase levels ( 29403010)	Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163) Kawasaki disease ( 21326860)
Interacting Genes		38 interacting genes: BTBD1 BTBD2 EWSR1 LGALS8 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5	3 interacting genes: MTNR1B TOP1 TRIM5
Entrez ID		85363	53339
HPRD ID		07004	12251
Ensembl ID		ENSG00000132256	ENSG00000064726
Uniprot IDs		Q9C035	A0A024R224 Q9H0C5
PDB IDs		2ECV 2YRG
Enriched GO Terms of Interacting Partners?
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