PAX9 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PAX9	TLE2
Description		paired box 9	TLE family member 2, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Breast cancer ( 29059683 23535729) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)
Interacting Genes		11 interacting genes: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		5083	7089
HPRD ID		01336	03025
Ensembl ID		ENSG00000198807	ENSG00000065717
Uniprot IDs		P55771 Q2L4T1	K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?
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