P4HB and ERO1A

Number of citations of the paper that reports this interaction (PubMedID 11707400)
87

Data Source:
HPRD (in vivo)

		P4HB	ERO1A
Description		prolyl 4-hydroxylase subunit beta	endoplasmic reticulum oxidoreductase 1 alpha
Image
GO Annotations	Cellular Component	Extracellular Region Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Dendrite Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Enzyme Binding Protein Heterodimerization Activity	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor
	Biological Process	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Oxidation-reduction Process Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Protein Folding Cellular Protein Modification Process Response To Temperature Stimulus Animal Organ Senescence Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Brown Fat Cell Differentiation Chaperone Cofactor-dependent Protein Refolding Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia
Pathways		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling	Insulin processing Detoxification of Reactive Oxygen Species
Drugs		Zinc Ribostamycin Copper
Diseases
GWAS			Heel bone mineral density ( 30598549)
Interacting Genes		22 interacting genes: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1A ERO1B ESR1 FEZ1 HNRNPD ITGB3 LGALS9 LINC00839 P4HA2 P4HA3 PRNP PTN TG UBQLN1 VWF YWHAG	10 interacting genes: APPBP2 EBF1 ERP44 GPX7 GPX8 P4HB PDIA3 PDILT PELI2 RHOU
Entrez ID		5034	30001
HPRD ID		07181	13278
Ensembl ID		ENSG00000185624	ENSG00000197930
Uniprot IDs		A0A024R8S5 P07237	Q96HE7
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S	3AHQ 3AHR
Enriched GO Terms of Interacting Partners?
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