P4HB and HNRNPD

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		P4HB	HNRNPD
Description		prolyl 4-hydroxylase subunit beta	heterogeneous nuclear ribonucleoprotein D
Image
GO Annotations	Cellular Component	Extracellular Region Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Enzyme Binding Protein Heterodimerization Activity	AT DNA Binding Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Oxidation-reduction Process Cellular Response To Hypoxia Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome Liver Development Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process RNA Metabolic Process Cerebellum Development Regulation Of Telomere Maintenance Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Regulation Of RNA Metabolic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity Hepatocyte Dedifferentiation
Pathways		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Zinc Ribostamycin Copper	Artenimol
Diseases
GWAS			Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		22 interacting genes: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1A ERO1B ESR1 FEZ1 HNRNPD ITGB3 LGALS9 LINC00839 P4HA2 P4HA3 PRNP PTN TG UBQLN1 VWF YWHAG	88 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPF HNRNPH3 HNRNPK HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TNPO1 TRN-GTT2-7 TSEN34 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		5034	3184
HPRD ID		07181	03206
Ensembl ID		ENSG00000185624	ENSG00000138668
Uniprot IDs		A0A024R8S5 P07237	A0A024RDB4 A0A024RDF4 A1LU37 Q14103
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S	1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?
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