ERO1A and EBF1

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		ERO1A	EBF1
Description		endoplasmic reticulum oxidoreductase 1 alpha	EBF transcription factor 1
Image
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Dendrite Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Protein Folding Cellular Protein Modification Process Response To Temperature Stimulus Animal Organ Senescence Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Brown Fat Cell Differentiation Chaperone Cofactor-dependent Protein Refolding Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia	Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Insulin processing Detoxification of Reactive Oxygen Species	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Anorexia nervosa (excluding migration to or from binge-eating disorder or bulimia nervosa) ( 28630421) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Blood protein levels ( 29875488) Breast cancer ( 29059683 23535729 23535733) Carotid intima media thickness ( 26343869) Cognitive decline rate in late mild cognitive impairment ( 26252872) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 28135244 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hip circumference (psychosocial stress interaction) ( 25271088) Hypertension ( 21909115 30487518) Hypospadias ( 25108383) Inflammatory skin disease ( 25574825) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Lymphocyte percentage of white cells ( 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534) Post bronchodilator FEV1 ( 26634245) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30224653 28135244 27841878 28739976 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		10 interacting genes: APPBP2 EBF1 ERP44 GPX7 GPX8 P4HB PDIA3 PDILT PELI2 RHOU	8 interacting genes: ATPAF2 CREBBP ERO1A HOMEZ MTNR1B PAX5 ZNF423 ZNF521
Entrez ID		30001	1879
HPRD ID		13278	01256
Ensembl ID		ENSG00000197930	ENSG00000164330
Uniprot IDs		Q96HE7	B4E2U8 Q9UH73
PDB IDs		3AHQ 3AHR	3LYR 3MQI
Enriched GO Terms of Interacting Partners?
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