NTRK2 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 9507002)
22

Data Source:
HPRD (in vivo)

		NTRK2	SHC3
Description		neurotrophic receptor tyrosine kinase 2	SHC adaptor protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Axon Dendrite Early Endosome Membrane Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Perinuclear Region Of Cytoplasm	Cellular_component Cytosol Plasma Membrane Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding
	Biological Process	Vasculogenesis Neuron Migration Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Multicellular Organism Development Nervous System Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Mechanoreceptor Differentiation Regulation Of GTPase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development Learning Or Memory Synaptic Transmission, Glutamatergic
Pathways		NGF-independant TRKA activation BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs		Amitriptyline
Diseases		Neuroblastoma
GWAS		Birth weight ( 24950379) Body mass index ( 28892062 25760438) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)	Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		33 interacting genes: AP1B1 BDNF DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB	16 interacting genes: ALK APP ARHGAP32 AXL EGFR ERBB2 ERBB3 FLT4 GOLGA2 GRB2 KRT31 KRT40 NTRK1 NTRK2 RET SH3GL3
Entrez ID		4915	53358
HPRD ID		02712	12005
Ensembl ID		ENSG00000148053	ENSG00000148082
Uniprot IDs		A0A024R230 Q16620 Q548C2 Q5VWE5	Q92529
PDB IDs		1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?