SHC3 and ALK

Number of citations of the paper that reports this interaction (PubMedID 12185581)
29

Data Source:
HPRD (in vivo)

		SHC3	ALK
Description		SHC adaptor protein 3	ALK receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Synapse	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Axon Guidance Central Nervous System Development Learning Or Memory Synaptic Transmission, Glutamatergic	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Positive Regulation Of Dendrite Development
Pathways		Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs			ATP Crizotinib Ceritinib Alectinib Brigatinib
Diseases			Non-small cell lung cancer
GWAS		Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Systolic blood pressure ( 26969751)
Interacting Genes		16 interacting genes: ALK APP ARHGAP32 AXL EGFR ERBB2 ERBB3 FLT4 GOLGA2 GRB2 KRT31 KRT40 NTRK1 NTRK2 RET SH3GL3	16 interacting genes: DUSP19 ERBB2 IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1
Entrez ID		53358	238
HPRD ID		12005	00104
Ensembl ID		ENSG00000148082	ENSG00000171094
Uniprot IDs		Q92529	B6D4Y2 Q9UM73
PDB IDs			2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8
Enriched GO Terms of Interacting Partners?
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