NRAP and TLN1

Number of citations of the paper that reports this interaction (PubMedID 10320340)
18

Data Source:
HPRD (in vitro)

		NRAP	TLN1
Description		nebulin related anchoring protein	talin 1
Image		No pdb structure
GO Annotations	Cellular Component	Fascia Adherens Muscle Tendon Junction Z Disc	Ruffle Extracellular Region Cell Cytosol Cytoskeleton Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Biological_process Muscle Fiber Development Cardiac Muscle Thin Filament Assembly	Platelet Degranulation Muscle Contraction Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation
Pathways			Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Plasma factor VII activating protease levels ( 30070759)	IgE levels in asthmatics ( 23967269) Platelet distribution width ( 27863252)
Interacting Genes		8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL	26 interacting genes: ACTA1 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ
Entrez ID		4892	7094
HPRD ID		04189	01726
Ensembl ID		ENSG00000197893	ENSG00000137076
Uniprot IDs		A0A0A0MRM2 Q86VF7	Q9Y490
PDB IDs			1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?
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