NPR1 and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 12855709)
8

Data Source:
HPRD (in vitro, two hybrid)

		NPR1	PRKG1
Description		natriuretic peptide receptor 1	protein kinase cGMP-dependent 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Diameter Regulation Of Cardiac Conduction	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Physiological factors	Ca2+ pathway
Drugs		Nitroprusside Nitroglycerin Isosorbide Dinitrate Amyl Nitrite Erythrityl Tetranitrate Nesiritide Ularitide
Diseases
GWAS		Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol misuse (trauma interaction) ( 28265120) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Chlamydia trachomatis seropositivity ( 29967566) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2	35 interacting genes: ANXA7 AR CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRPC3 VASP WDR77 ZNF646
Entrez ID		4881	5592
HPRD ID		00165	08910
Ensembl ID		ENSG00000169418	ENSG00000185532
Uniprot IDs		A0A140VJE6 P16066	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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