PRKG1 and TRIM39-RPP21

Number of citations of the paper that reports this interaction (PubMedID 17601797)
3

Data Source:
BioGRID (two hybrid)

		PRKG1	TRIM39-RPP21
Description		protein kinase cGMP-dependent 1	TRIM39-RPP21 readthrough
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Ca2+ pathway
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol misuse (trauma interaction) ( 28265120) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Chlamydia trachomatis seropositivity ( 29967566) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Gait rhythm ( 26219847) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Triglyceride levels x loop diuretics use interaction ( 31806883)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Feeling guilty ( 29500382) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Neuroticism ( 29255261) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		35 interacting genes: ANXA7 AR CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRPC3 VASP WDR77 ZNF646	1 interacting genes: PRKG1
Entrez ID		5592	202658
HPRD ID		08910
Ensembl ID		ENSG00000185532	ENSG00000248167
Uniprot IDs		Q13976	A0A096LP39 A6ZJ12
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T
Enriched GO Terms of Interacting Partners?
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