NEK3 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 15618286)
26

Data Source:
HPRD (in vivo)

		NEK3	PRLR
Description		NIMA related kinase 3	prolactin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Axon	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Tubulin Deacetylation	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity JAK-STAT Cascade Embryo Implantation Lactation Response To Bacterium Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Positive Regulation Of Cold-induced Thermogenesis
Pathways			Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Fluoxymesterone
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		6 interacting genes: BPGM CDCA8 NMNAT1 PRLR VAV1 VAV2	19 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 JAK2 MFGE8 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		4752	5618
HPRD ID		04954	01457
Ensembl ID		ENSG00000136098	ENSG00000113494
Uniprot IDs		P51956 Q6ZN64	P16471
PDB IDs			1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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