PRLR and PRL

Number of citations of the paper that reports this interaction (PubMedID 9626554)
241

Data Source:
HPRD (in vivo, in vitro)

		PRLR	PRL
Description		prolactin receptor	prolactin
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex	Extracellular Region Extracellular Space Endosome Lumen
	Molecular Function	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding	Prolactin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity JAK-STAT Cascade Embryo Implantation Lactation Response To Bacterium Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Endothelial Cell Proliferation Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Positive Regulation Of Cell Proliferation Negative Regulation Of Angiogenesis Mammary Gland Development Response To Nutrient Levels Regulation Of Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Lactation
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling
Drugs		Somatotropin Fluoxymesterone
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)	Chronic obstructive pulmonary disease ( 30804561) Obesity ( 19151714) Paget's disease ( 21623375) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		19 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 JAK2 MFGE8 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	4 interacting genes: PPIB PRLR SCARB1 UBQLN4
Entrez ID		5618	5617
HPRD ID		01457	07180
Ensembl ID		ENSG00000113494	ENSG00000172179
Uniprot IDs		P16471	P01236 Q5I0G2 Q5THQ0
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18	1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
Enriched GO Terms of Interacting Partners?
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