PRLR and TEC

Number of citations of the paper that reports this interaction (PubMedID 11328862)
10

Data Source:
HPRD (in vivo, in vitro)

		PRLR	TEC
Description		prolactin receptor	tec protein tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity JAK-STAT Cascade Embryo Implantation Lactation Response To Bacterium Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Positive Regulation Of Cold-induced Thermogenesis	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs		Somatotropin Fluoxymesterone
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)
Interacting Genes		19 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 JAK2 MFGE8 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	31 interacting genes: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG FBXO7 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		5618	7006
HPRD ID		01457	02786
Ensembl ID		ENSG00000113494	ENSG00000135605
Uniprot IDs		P16471	P42680
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18	2LUL
Enriched GO Terms of Interacting Partners?
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