DRG1 and PHC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		DRG1	PHC2
Description		developmentally regulated GTP binding protein 1	polyhomeotic homolog 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Membrane Nuclear Body	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Microtubule Binding Transcription Factor Binding Potassium Ion Binding Identical Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Cytoplasmic Translation Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Microtubule Polymerization Regulation Of Mitotic Spindle Assembly	Multicellular Organism Development Spermatogenesis
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252)	Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		13 interacting genes: CAPNS1 CLDN1 COIL LYL1 PHC2 RWDD1 SKIL SRPK2 SSX2IP STK16 TAL1 UBE2I ZC3H15	71 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 H3-4 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417
Entrez ID		4733	1912
HPRD ID		16034	10340
Ensembl ID		ENSG00000185721	ENSG00000134686
Uniprot IDs		Q9Y295	A0A0A0MSI2 Q8IXK0
PDB IDs		2EKI
Enriched GO Terms of Interacting Partners?
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