PHC2 and SCMH1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PHC2	SCMH1
Description		polyhomeotic homolog 2	Scm polycomb group protein homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleoplasm Chromocenter
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding	Protein Binding
	Biological Process	Multicellular Organism Development Spermatogenesis	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs			Beta-Mercaptoethanol
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435)
Interacting Genes		71 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 H3-4 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417	16 interacting genes: EWSR1 GMNN HK1 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M TMEM11 TOB1 UBQLN1 UBQLN4
Entrez ID		1912	22955
HPRD ID		10340	11540
Ensembl ID		ENSG00000134686	ENSG00000010803
Uniprot IDs		A0A0A0MSI2 Q8IXK0	B3KMZ7 Q96GD3
PDB IDs			2P0K
Enriched GO Terms of Interacting Partners?
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