PHC2 and MFAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PHC2	MFAP1
Description		polyhomeotic homolog 2	microfibril associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Microfibril Extracellular Region Nucleus Nucleoplasm Centrosome U2-type Precatalytic Spliceosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Multicellular Organism Development Spermatogenesis	MRNA Splicing, Via Spliceosome
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
Interacting Genes		71 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 H3-4 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417	47 interacting genes: AMOTL2 BEND7 CARD9 CCDC57 CDCA7L CEP55 CEP57L1 CEP70 COIL CSNK2A1 DHX38 DHX8 FAM9B FRA10AC1 FXR2 GKAP1 GOLGA2 HMBOX1 HSPB1 IK KATNBL1 KIFC3 KRT40 LDOC1 LMNA MAD1L1 MID2 MIPOL1 MTUS2 NDC80 PHC2 SART1 SNIP1 SNW1 SSX2IP STX11 TADA2A TLE5 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB14 ZBTB8A ZFP64 ZNF398
Entrez ID		1912	4236
HPRD ID		10340	02569
Ensembl ID		ENSG00000134686	ENSG00000140259
Uniprot IDs		A0A0A0MSI2 Q8IXK0	P55081
PDB IDs			5F5S 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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