PHC2 and SDCBP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PHC2	SDCBP
Description		polyhomeotic homolog 2	syndecan binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Adaptor Activity Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Multicellular Organism Development Spermatogenesis	Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Phosphorylation Neutrophil Degranulation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Ephrin signaling Neurofascin interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		71 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CBX2 CRK CRKL CSNK2B DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 GFI1B GRB2 H3-4 KAT5 KBTBD7 KDM1A KIFC3 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MORF4L2 NCK1 PCGF2 PCGF3 PCGF5 PHC1 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 ZBTB24 ZGPAT ZMAT2 ZNF417	173 interacting genes: ABI2 ANKRD40 ANP32B APIP BCL2L15 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CBY2 CCDC102B CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DCTD DCTPP1 DMC1 DRAP1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 ENTR1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IHO1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RPL22 RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SEPTIN3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBC UBE2A ULK1 WASHC3 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17
Entrez ID		1912	6386
HPRD ID		10340	03741
Ensembl ID		ENSG00000134686	ENSG00000137575
Uniprot IDs		A0A0A0MSI2 Q8IXK0	A0A024R7Z5 B4DHN5 G5EA09 O00560
PDB IDs			1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33
Enriched GO Terms of Interacting Partners?
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