MSX2 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		MSX2	TLE2
Description		msh homeobox 2	TLE family member 2, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytosol Nuclear Speck	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Coregulator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Chondrocyte Development Osteoblast Development Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endochondral Bone Growth Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of CREB Transcription Factor Activity Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Wound Healing, Spreading Of Epidermal Cells Embryonic Nail Plate Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Stem Cell Differentiation Positive Regulation Of Timing Of Catagen Bone Trabecula Formation Cranial Suture Morphogenesis Frontal Suture Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis BMP Signaling Pathway Involved In Heart Development Enamel Mineralization Cellular Response To Estradiol Stimulus Activation Of Meiosis Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Regulation of RUNX2 expression and activity	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Enlarged parietal foramina/cranium bifidum Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		23 interacting genes: ATXN1 CEBPA DLX2 DLX5 GTF2F1 GTF2F2 MAGED1 MAT2B MSX1 NR3C1 PIAS2 POLR3D POU2AF1 PPARG RUNX2 SPEN TLE1 TLE2 USP54 XRCC5 XRCC6 ZBTB17 ZDHHC2	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		4488	7089
HPRD ID		00421	03025
Ensembl ID		ENSG00000120149	ENSG00000065717
Uniprot IDs		P35548	K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?
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