USP4 and NOLC1

Number of citations of the paper that reports this interaction (PubMedID 11571651)
7

Data Source:
HPRD (in vivo)

		USP4	NOLC1
Description		ubiquitin specific peptidase 4	nucleolar and coiled-body phosphoprotein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cajal Body Box C/D SnoRNP Complex Box H/ACA SnoRNP Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase I Core Binding DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding ATP Binding GTP Binding Transcription Factor Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Box C/D SnoRNA Binding Box H/ACA SnoRNA Binding Protein Heterodimerization Activity Box C/D SnoRNP Complex Binding Box H/ACA SnoRNP Complex Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Response To Osmotic Stress Nucleolus Organization Positive Regulation Of Cell Proliferation Neural Crest Formation Neural Crest Cell Development Box H/ACA SnoRNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs			Doxorubicin
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		47 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A CIAO2B HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	16 interacting genes: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B KBTBD8 MDM2 POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ
Entrez ID		7375	9221
HPRD ID		04598	03864
Ensembl ID		ENSG00000114316	ENSG00000166197
Uniprot IDs		A0A024R2X6 A1LPW7 Q08AK7 Q13107	B2RAU8 Q14978 Q96J17
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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