MSH4 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 12095912)
35

Data Source:
HPRD (in vitro)

		MSH4	MLH3
Description		mutS homolog 4	mutL homolog 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Synaptonemal Complex Nucleus Recombination Nodule	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	DNA Binding Protein Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Mismatch Repair Synapsis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730)
Interacting Genes		9 interacting genes: ACADM DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1	4 interacting genes: AR MLH1 MSH4 ZDHHC17
Entrez ID		4438	27030
HPRD ID		03658	05094
Ensembl ID		ENSG00000057468	ENSG00000119684
Uniprot IDs		O15457	Q2M1Z1 Q9UHC1
PDB IDs
Enriched GO Terms of Interacting Partners?
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