MSH4 and ACADM

		MSH4	ACADM
Description		mutS homolog 4	acyl-CoA dehydrogenase medium chain
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Synaptonemal Complex Nucleus Recombination Nodule	Nucleus Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane
	Molecular Function	DNA Binding Protein Binding DNA-dependent ATPase Activity Mismatched DNA Binding	Acyl-CoA Dehydrogenase Activity Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain-acyl-CoA Dehydrogenase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Mismatch Repair Synapsis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation	Fatty Acid Beta-oxidation Regulation Of Lipid Metabolic Process Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Oxidation-reduction Process
Pathways		Meiotic recombination	PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Drugs			Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-Thiaoctanoyl-Coenzyme A
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Acylcarnitine levels ( 26068415) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Daytime sleep phenotypes ( 27126917) Glycine levels ( 31070104 30837465) Metabolic traits ( 21886157) Metabolite levels ( 20037589) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		9 interacting genes: ACADM DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1	7 interacting genes: ABCD3 AGTR1 CALM1 DBT DIRAS3 MSH4 SUMO4
Entrez ID		4438	34
HPRD ID		03658	08447
Ensembl ID		ENSG00000057468	ENSG00000117054
Uniprot IDs		O15457	A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5HYG7 Q5T4U5
PDB IDs			1EGC 1EGD 1EGE 1T9G 2A1T 4P13
Enriched GO Terms of Interacting Partners?
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