MIP and FOXA2

Number of citations of the paper that reports this interaction (PubMedID 12642491)
18

Data Source:
HPRD (in vitro)

		MIP	FOXA2
Description		major intrinsic protein of lens fiber	forkhead box A2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Integral Component Of Membrane Apical Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Structural Constituent Of Eye Lens Calmodulin Binding Water Channel Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Lens Development In Camera-type Eye Water Transport Visual Perception Positive Regulation Of Cell Adhesion Response To Stimulus Protein Homotetramerization Transmembrane Transport Gap Junction-mediated Intercellular Transport	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways		Passive transport by Aquaporins	Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		Axial length ( 24144296)	Adolescent idiopathic scoliosis ( 25784220) Birth weight ( 31043758) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458) Vitamin D levels ( 26704534)
Interacting Genes		10 interacting genes: CALM1 CRYAA CRYAB CRYBB2 CRYGC FOXA2 GJA3 GJA8 LMNA PRKACA	9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		4284	3170
HPRD ID		01098	02618
Ensembl ID		ENSG00000135517	ENSG00000125798
Uniprot IDs		P30301	B0ZTD4 Q9Y261
PDB IDs			5X07
Enriched GO Terms of Interacting Partners?
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