FOXA2 and EN2

Number of citations of the paper that reports this interaction (PubMedID 12642491)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FOXA2	EN2
Description		forkhead box A2	engrailed homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Membrane RSC-type Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Factor Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding
	Biological Process	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Neuron Differentiation Midbrain Development Hindbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Embryonic Brain Development
Pathways		Regulation of gene expression in beta cells
Drugs			N-Cyclohexyltaurine
Diseases
GWAS		Adolescent idiopathic scoliosis ( 25784220) Birth weight ( 31043758) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458) Vitamin D levels ( 26704534)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1	1 interacting genes: FOXA2
Entrez ID		3170	2020
HPRD ID		02618	08836
Ensembl ID		ENSG00000125798	ENSG00000164778
Uniprot IDs		B0ZTD4 Q9Y261	P19622
PDB IDs		5X07
Enriched GO Terms of Interacting Partners?
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