RAB8A and OPTN

Number of citations of the paper that reports this interaction (PubMedID 11137014)
68

Data Source:
HPRD (two hybrid)

		RAB8A	OPTN
Description		RAB8A, member RAS oncogene family	optineurin
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GO Annotations	Cellular Component	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Endomembrane System Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Ciliary Basal Body Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding GDP Binding Protein Kinase Binding Myosin V Binding	Protein Binding Protein C-terminus Binding Rab GTPase Binding Protein Binding, Bridging Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)
Interacting Genes		34 interacting genes: ASNS BAG6 BIRC6 GDI2 IKBKG JAK3 KCNN1 MALT1 MAP4K2 MDM2 MYO5C MYO9B NR2F6 OCRL ODF2 OPTN PDE6D PQBP1 PRKACA RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL STEAP1 SYTL1 SYTL4 TAS2R9 TFRC TPM4 UGT2B15	46 interacting genes: ATG16L1 ATG5 CALM1 CDC23 DAZAP2 EPS15 FAM189A2 FLII FOS GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSPB1 HTT IRAK1 LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYO6 PIAS4 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 SLF2 SQSTM1 TBC1D15 TBC1D17 UBC UQCRQ WASHC3 WIPI2 ZNF329 ZNF398 ZNF670
Entrez ID		4218	10133
HPRD ID		01296	03891
Ensembl ID		ENSG00000167461	ENSG00000123240
Uniprot IDs		A0A024R7I3 P61006	Q96CV9
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI	2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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