OPTN and HACE1

Number of citations of the paper that reports this interaction (PubMedID 25026213)
60

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		OPTN	HACE1
Description		optineurin	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Protein Binding, Bridging Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Rab GTPase Binding Rac GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination
Pathways		Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)	Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448622 27182965) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		46 interacting genes: ATG16L1 ATG5 CALM1 CDC23 DAZAP2 EPS15 FAM189A2 FLII FOS GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSPB1 HTT IRAK1 LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYO6 PIAS4 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 SLF2 SQSTM1 TBC1D15 TBC1D17 UBC UQCRQ WASHC3 WIPI2 ZNF329 ZNF398 ZNF670	9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		10133	57531
HPRD ID		03891	17086
Ensembl ID		ENSG00000123240	ENSG00000085382
Uniprot IDs		Q96CV9	Q8IYU2
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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