OPTN and TBC1D15

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		OPTN	TBC1D15
Description		optineurin	TBC1 domain family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Extracellular Region Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Rab GTPase Binding Protein Binding, Bridging Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy	Intracellular Protein Transport Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs	TBC/RABGAPs
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)	Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)
Interacting Genes		46 interacting genes: ATG16L1 ATG5 CALM1 CDC23 DAZAP2 EPS15 FAM189A2 FLII FOS GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSPB1 HTT IRAK1 LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYO6 PIAS4 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 SLF2 SQSTM1 TBC1D15 TBC1D17 UBC UQCRQ WASHC3 WIPI2 ZNF329 ZNF398 ZNF670	8 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C UBC
Entrez ID		10133	64786
HPRD ID		03891	15470
Ensembl ID		ENSG00000123240	ENSG00000121749
Uniprot IDs		Q96CV9	A8K8E1 Q8TC07
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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