MEF2C and SMAD2

  • Number of citations of the paper that reports this interaction (PubMedID 11160896)
  • 21

MEF2C

SMAD2

Description myocyte enhancer factor 2C SMAD family member 2
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Accelerometer-based physical activity measurement (average acceleration) ( 29899525)
  • Alcohol consumption ( 31358974)
  • Alcohol consumption (drinks per week) ( 30643258)
  • Alzheimer's disease ( 31473137)
  • Alzheimer's disease (late onset) ( 24162737)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention deficit hyperactivity disorder ( 29325848)
  • Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268)
  • Body mass index ( 26426971)
  • Bone mineral density ( 21533022 24249740 23572186)
  • Bone mineral density (hip) ( 19801982)
  • Bone mineral density (total hip) ( 29883787)
  • Bone mineral density (Ward's triangle area) ( 27397699)
  • Chronotype ( 30696823)
  • Cognitive ability ( 29186694)
  • Cognitive ability (MTAG) ( 29186694)
  • Depression ( 29700475)
  • Femoral neck bone mineral density ( 29499414 22504420)
  • General cognitive ability ( 29844566)
  • Glomerular filtration rate in chronic kidney disease ( 26420894)
  • Height ( 20881960 25282103 25429064)
  • Household income (MTAG) ( 31844048)
  • Intelligence ( 28530673)
  • Intelligence (MTAG) ( 29326435)
  • Major depressive disorder ( 27479909)
  • Mean corpuscular hemoglobin ( 27863252)
  • Mean corpuscular volume ( 27863252)
  • Mean platelet volume ( 22139419 27863252)
  • Morning person ( 30696823)
  • Multiple sclerosis ( 31604244)
  • Number of sexual partners ( 30643258)
  • Photic sneeze reflex ( 27182965)
  • Platelet count ( 22139419 27863252)
  • Platelet distribution width ( 27863252)
  • Plateletcrit ( 27863252)
  • Red blood cell count ( 27863252)
  • Regular attendance at a religious group ( 29970889)
  • Retinal arteriolar caliber ( 23776548)
  • Retinal vascular caliber ( 21060863)
  • Rosacea symptom severity ( 29771307)
  • Schizophrenia ( 25056061 30285260)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
  • Tonometry ( 17903302)
  • Vascular endothelial growth factor levels ( 26910538)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for body mass index ( 28448500)
  • Coronary artery disease in type 1 diabetes ( 29695241)
  • Lung cancer in ever smokers ( 28604730)
  • Menarche (age at onset) ( 27182965)
Interacting Genes 30 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ 209 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF8 ZNHIT6
Entrez ID 4208 4087
HPRD ID 02809 03221
Ensembl ID ENSG00000081189 ENSG00000175387
Uniprot IDs A0A024RAL6 A0A024RAL7 A0A0D9SGI5 D8L7E9 Q06413 B7Z5N5 Q15796 Q53XR6
PDB IDs 1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R
Enriched GO Terms of Interacting Partners?
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